Nicotinamide adenine dinucleotide (53-84-9) vitio
Nicotinamide dinucleotide adenine (53-84-9) Sfaʻamatalaga
Igoa oloa | Nicotinamide adenine dinucleotide (NAD +) |
Suafa Suafa | Nadide; o le faʻamaoni, o le ATUA, o le Peta-Natano, o le peta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride; |
Numera CAS | 53-84-9 |
InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
Faiga Faʻavae Molecular | C21H27N7O14P2 |
Taumaʻa Masele | 663.4 g / mol |
Masima Monoisotopic | 663.109123 g / mol |
Melting Point | 160 ° C (320 ° F; 433 K) |
lanu | Lanu pa'epa'e |
Stora temp | 2-8 ° C |
Solubility | H2O: 50 mg / mL |
talosaga | Soifua Maloloina, mea teuteu, meaʻai fafaga |
O le a Nicotinamide adenine dinucleotide(NAD +)?
Nicotinamide adenine dinucleotide (NAD) o se tagata e gafa ma fesoasoani i le metabolism e maua i suauu ola uma. E lua ituaiga, oxidized (NAD +) ma faʻaititia (NADH).
O Coenzyme NAD +, o le ituaiga o NAD, na maua muamua i le 1906 e tagata suʻesuʻe mai le au Peretania o Arthur Harden ma William John Young. O le NAD + o loʻo faʻapipiʻiina e auala e lua, e mafai ona gaosia mai le auala o le novo amino acid, pe mafai ona gaosia e ala i le toe faʻaaogaina o vaega muamua na fausia (pei o le nicotinamide) i le ala laveaʻi o le NAD +. E taua tele le nucleotide pyridine ma e avea o se mea taua tele ma se mea e fai mo le tele o auala telefoni feaveaʻi e aofia ai le gaosiga o le phosphorylation ma le ATP, gaioiga o DNA, tulafono a le epigenetic regulatory gene expression, faailo o le calcium intracellular ma le Immunological function.
NAD + o le elemene taliaina tele eletise i le faʻamaʻiina o meaola. E talia eletise mai isi meaola ma ua faʻaititia. E galue foi e avea o se coenzyme o le fesuiaiga o le vavave ma se mea e faaaoga ai le NAD (+) polymerase, ma fai ai se paʻu o le coenzyme ma le faaitiitia o le β-nicotinamide adenine dinucleotide (NADH). O le NAD (R) o le ADB-ribose foaʻi i le ADP-A. O se vailaau muamua foi i le ADP-ribose (ADP-ribosyl cyclase).
I le avea ai o se oxidant i sela metabolism, NAD (R) e faʻatinoina foi sona sao i le adenosine diphosphate (ADP) -ribose faʻaliliuina tali e aofia ai le diadenylate (ADP-ribose) polymerase ma le tele o isi enzymatic gaioiga. E mafai ona puipuia puipuia NAD e puipuia pe faʻaititia le maʻisuka, kanesa ma isi faʻamaʻi fesoʻotaʻi tausaga. E le gata i lea, o le NAD + boosters e mafai ona galulue faʻatasi ma faʻaopopoga e pei o le resveratrol e fesoasoani e faʻafou ai le mitochondria ma teteʻe ai i faʻamaʻi ua matutua.
Nicotinamide adenine dinucleotide(NAD +) manuia
I le avea ai o se faʻamaʻi ola maloloina, o le Nicotinamide adenine dinucleotide o loʻo faʻaalia ai nisi o lelei lelei i gaoioiga a tagata.
♦ Faʻalelei lau gaioiga feaveaʻi,
♦ Faateleina lou malosi masani;
♦ Faʻaleleia le faiʻai, taulaʻi ma manatua;
♦ Faʻaleleia lou metabolism;
♦ Faʻaleleia le moe;
♦ Faʻaleleia le gaioiga a le lalolagi;
♦ Faʻaleleia le malosi o le antioxidant;
♦ Faʻaitiitia le mumu;
♦ Faʻaleleia le paleni, lagona, vaʻai ma faʻalogo;
Nicotinamide adenine dinucleotid o se taulaʻiga tuʻusaʻo foi o le vailaʻau isoniazid, lea e faʻaaogaina i le togafitia o le tuberculosis, o se faʻamaʻi e mafua mai i le Mycobacterium tuberculosis. I le tasi faʻataʻitaʻiga, o isumu na tuʻuina atu i le NAD mo le tasi le vaiaso na faʻaleleia atili ai le fesoʻotaʻiga o le eletise-mitochrondrial.
E le gata i lea, o le Nicotinamide adenine dinucleotide (NAD +) e iai foi le puipuiga ma le togafitia o poloka fatu, galuega o le pona o le sinusus ma le faʻataʻitaʻiga o arthhythmias, o le nicotinamide e mafai ona faʻaleleia atili ai le fatu ma le poloka o le atriove e mafua mai i verapamil.
Nicotinamide adenine dinucleotide(NAD +) talosaga:
- Faʻataʻitaʻiga o mea e faʻaaoga ai suʻesuʻega faʻasaienisi.
- Soifua Maloloina, mea teuteu, meaʻai fafaga
- Faʻaauau API
nisi Nicotinamide adenine dinucleotide(NAD +) suesuega
O enzymes e gaosia ma faʻaaogaina le NAD + ma le NADH e taua uma i le falemaʻi ma le suʻesuʻega i togafitiga i le lumanaʻi mo faʻamaʻi. O le coenzyme NAD + e leʻo faʻaaogaina nei mo togafitiga o se faʻamaʻi. Peitaʻi, o loʻo suʻesuʻeina mo lona ono faʻaaogaina i le togafiti o faʻamaʻi neurodegenerative pei oAlzheimer ma le faʻamaʻi Parkinson.
Tusitaiala o le:
- Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism i le soifua maloloina ma faʻamaʻi" (PDF). Faʻavae Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Faʻamaumauga mai le uluaʻi (PDF) i le aso 4 Iulai 2009. Toe aumai 23 Tesema 2007.
- Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Faʻailoaina o le mitochondrial NAD + felauaiga i Saccharomyces cerevisiae". J. Biol. Chem. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
- Lin SJ, Guarente L (Aperila 2003). "Nicotinamide adenine dinucleotide, o se metabolic regulator o tusitusiga, umi le ola ma faʻamaʻi". Faʻamatalaga Manatu Sela Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
- Williamson DH, Lund P, Krebs HA (1967). "O le redox tulaga o saoloto nikotinamide-adenine dinucleotide i le cytoplasm ma mitochondria o isumu ate". Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
- Foster JW, Moat AG (1 Mati 1980). "Nicotinamide adenine dinucleotide biosynthesis ma pyridine nucleotide cycle metabolism i microbial system". Microbiol. Faʻaaliga 44 (1): 83– PMC 373235. PMID 6997723.
- Farani Farani. O le inuina o le ava malosi e afaina ai le ate ma isi totoga e ala i le faʻaititia o le NAD⁺ maualuga e manaʻomia mo le sirtuin's deacetylase. Exp Mol Pathol. 2016 Ape; 100 (2): 303-6. fai: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Fepuari 16. PMID: 26896648.
- Kane AE, Sinclair DA. Sirtuins ma le NAD + i le Atinaʻeina ma le togafitia o faʻamaʻi ma le gasegase o le cardiovascular. Circ Res. 2018 Sep. 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.